Quinine Hydrochloride(130-89-2)Antimalarial&Fever reduction API

Quinine Hydrochloride is a natural alkaloid derived from cinchona bark, primarily recognized for its potent antimalarial properties. It is indicated for the treatment of severe or chloroquine-resistant Plasmodium falciparum malaria, acting as a rapidly acting blood schizonticide that disrupts the parasite’s ability to digest hemoglobin within infected red blood cells. While historically utilized for the prevention and treatment of nocturnal leg cramps, contemporary clinical guidelines strongly discourage this use due to the risk of severe, potentially life-threatening adverse effects such as thrombocytopenia, QT prolongation, and cinchonism. Consequently, its clinical administration is strictly reserved for acute malarial infections under close medical supervision.