Dihexa is an investigational synthetic oligopeptide compound, structurally derived from angiotensin IV, that has garnered significant research interest due to its remarkable cognitive-enhancing and neurogenic properties. Chemically designated as N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, it represents a rationally designed analogue with enhanced metabolic stability and blood-brain barrier penetration compared to its parent peptide. Its primary mechanism of action involves binding to and activating the c-Met receptor, the endogenous receptor for hepatocyte growth factor, a pleiotropic cytokine involved in development, tissue repair, and synaptic plasticity. Upon binding to c-Met, Dihexa triggers autophosphorylation of the receptor and subsequent activation of downstream signaling cascades, including the phosphatidylinositol 3-kinase/Akt pathway and the mitogen-activated protein kinase pathway.
Dihex (CAS 1401708-83-5) – Cognitive Enhancement Memory Improvement
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Dihexa (development code PNB-0408) is a synthetic oligopeptide drug derived from angiotensin IV. It was designed as a potent nootropic drug, primarily by activating hepatocyte growth factor (HGF) and its receptor c-Met pathway to promote the formation of new synapses in the brain (synapsis).
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