Dapoxetine(CAS 119356-77-3)Premature ejaculation (PE) treatment

Dapoxetine (widely marketed under the brand name Priligy) is a fast-acting, short-lived selective serotonin reuptake inhibitor (SSRI). Unlike traditional SSRIs used as daily antidepressants, Dapoxetine was uniquely designed and is clinically indicated specifically for the on-demand treatment of premature ejaculation (PE) in adult men aged 18 to 64.The medication works efficiently by inhibiting the serotonin reuptake transporter, which increases the synaptic levels of serotonin within the central nervous system. This biochemical action delays the ejaculatory reflex and extends the intravaginal ejaculatory latency time (IELT). By modulating the pathways responsible for ejaculation, Dapoxetine significantly enhances ejaculatory control and substantially reduces personal distress or interpersonal difficulty associated with the condition.