Mazdutide is a novel, long-acting dual agonist that targets both the GLP-1 and glucagon receptors, mimicking the natural hormone oxyntomodulin to drive comprehensive metabolic regulation. By activating the GLP-1 receptor, it effectively suppresses appetite, delays gastric emptying, and improves glycemic control, while its activation of the glucagon receptor uniquely boosts energy expenditure and accelerates hepatic fat metabolism. Clinical data demonstrates that this “dual metabolic engine” delivers profound reductions in body weight and waist circumference, lowers liver fat, and significantly improves cardiometabolic risk factors, making it a breakthrough therapeutic candidate for obesity and type 2 diabetes.
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